Frown lines form when facial expressions are made as the muscle under the skin contracts. Over time, as your skin ages, these repeated expressions cause lasting frown lines. Neurotoxins, such as Xeomin, are prescription medications that block the release of the chemicals that cause these muscle contractions so frown lines are softened.
XEOMIN® was proven effective in two randomized, double-blind, multi-center, placebo-controlled clinical trials of 547 healthy, adult patients. The average age of patients in the study was 46 years. Treatment success was higher with XEOMIN® than placebo on Day 30 in both studies (60% and 48% vs. 0% for placebo in both studies). Based on these trials, XEOMIN® received FDA approval for use in glabellar (frown) lines in 2011.
During treatment, which usually takes about 10-20 minutes, your doctor will inject XEOMIN® into the muscles in your forehead that cause frown lines between your eyebrows. No anesthesia is required, however, your physician may use a topical anesthetic or cold pack to reduce any discomfort.
You may begin to see visible smoothing as early as 3-4 days after injection. The median first onset of effect was less than a week. The maximum effect occurred at 30 days. The typical duration of effect was up to 3 months in clinical trials but may last significantly longer or shorter depending on the individual patient.
Read the medication guide before you start receiving XEOMIN® (Zeo-min) and each time XEOMIN® is given to you as there may be new information. The risk information provided here is not comprehensive.
To learn more:
XEOMIN® is a prescription medicine that is injected into muscles and used to improve the look of moderate to severe frown lines between the eyebrows (glabellar lines) in adults for a short period of time (temporary).
XEOMIN® may cause serious side effects that can be life-threatening. Call your doctor or get medical help right away if you have any of these problems, any time (hours to weeks) after treatment with XEOMIN®:
Problems with swallowing, speaking, or breathing. These problems can happen hours to weeks after an injection of XEOMIN®. Death can happen as a complication if you have severe problems with swallowing or breathing after treatment with XEOMIN®.
People with certain breathing problems who use muscles in their neck to help them breathe may be at a greater risk for serious breathing problems with XEOMIN®.
Swallowing problems may last for several months. People who cannot swallow well may need a feeding tube to receive food and water. If swallowing problems are severe, food or liquids may go into your lungs. People who already have swallowing or breathing problems before receiving XEOMIN® have the highest risk of getting these problems.
In some cases, the botulinum toxin may spread and affect areas of the body away from the injection site, causing symptoms of a serious condition called botulism. The symptoms of botulism include loss of strength and muscle weakness all over the body, double vision, blurred vision, drooping eyelids, hoarseness, change in or loss of voice, trouble saying words clearly, loss of bladder control, trouble breathing, and trouble swallowing. These problems could make it unsafe for you to drive a car or do other dangerous activities.
Do not use XEOMIN® if you are allergic to XEOMIN® or any of the ingredients in XEOMIN® (see the end of this guide for a list of ingredients in XEOMIN®), had an allergic reaction to any other botulinum toxin products such as rimabotulinumtoxinB (MYOBLOC®), onabotulinumtoxinA (BOTOX®, BOTOX® COSMETIC), or abobotulinumtoxinA (DISPORT®) or have a skin infection at the planned injection site.
Ask a doctor before use if you:
XEOMIN® is not recommended for use in children younger than 18 years of age.
Tell your doctor about all of your medical conditions and all of the medications you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Using XEOMIN® with some other medications may cause serious side effects. Do not start any new medications until you have told your doctor that you have received XEOMIN® in the past.
It’s especially important to tell your doctor if you have done any of the following:
Ask your doctor if you are not sure if your medicine is one that is listed above.
XEOMIN® can cause serious side effects that can be life-threatening. See “Warnings.”
Headache was the most common side effect of XEOMIN®. Other possible side effects include:
XEOMIN® may cause other serious side effects including allergic reactions. Symptoms of an allergic reaction to XEOMIN® may include itching, rash, redness, swelling, wheezing, asthma symptoms, or dizziness or feeling faint. Tell your doctor or get medical help right away if you get wheezing or asthma symptoms, or if you get dizzy or faint.
These are not all the possible side effects of XEOMIN®. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
XEOMIN® is a shot (injection) that your doctor will give you.
XEOMIN® is injected into your affected muscles.
Your doctor may change your dose of XEOMIN® until you and your doctor find the best dose for you.
Medications are sometimes prescribed for purposes other than those listed in a medication guide. Do not use XEOMIN® for a condition for which it was not prescribed. Do not give XEOMIN® to other people, even if they have the same symptoms that you have. It may harm them. You can ask your pharmacist or doctor for information about XEOMIN® that is written for health professionals.
Active Ingredient: incobotulinumtoxinA
Inactive Ingredients: human albumin and sucrose